Acorda Therapeutics may not actually achieve the goals or zanaflex dal messico plans described in its forward-looking statements, and investors should not place undue reliance on these statements. Concomitant use of tizanidine with CYP1A2 inhibitors should ordinarily be avoided. Products mentioned are trademarks, brands and patents of respective companies. PRECAUTIONS Cardiovascular Prolongation of the QT interval and bradycardia were noted in chronic toxicity studies in dogs at doses equal to the maximum human dose on mg m2 basis. If you have any of these conditions, you may not be able to use Zanaflex, or you may need dosage adjustment or special tests during treatment. Acorda, which has been working on the development of the drug since the mid-1990s, recently reached agreement with another biotech company, Biogen Idec of Cambridge, Mass.